![]() After multivariable adjustments, IHF was associated with increased odds for worsening and decreased odds for improvement (OR 0.35 95% CI 0.18–0.65 P < 0.001). IHF, the composite outcomes were worsened (19.1% vs. IHF ( n = 114), patients were younger (mean age 61.0 vs. Among the 364 patients analysed, 47 were not investigated for IHD. The associations between baseline characteristics and composite changes were analysed with multiple logistic regression. Treatment response was determined by use of a hierarchical clinical composite outcome classifying each patient as worsened, improved, or unchanged based on hard outcomes (mortality, heart transplantation, and HF hospitalization) and soft outcomes (± ≥10 unit change in LVEF, ± ≥30% change in N-terminal pro-B-type natriuretic peptide, and ± ≥1 point change in New York Heart Association functional class) during 28 weeks of follow-up. Patients hospitalized with recent-onset HFrEF between 1 January 2016 and 31 December 2019 were included. ischaemic (IHF) aetiology and evaluated the frequency of coronary investigation. ![]() In this study, we compared short-term response to initiated guideline-directed medical treatment (GDMT) in recent-onset HFrEF of non-ischaemic (non-IHF) vs. Infrequent diagnostic work-up for ischaemic heart disease (IHD) in HF is reported. In heart failure (HF) with reduced left ventricular ejection fraction (HFrEF), the prognosis appears better in non-ischaemic than in ischaemic aetiology. ![]()
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